Opioid microinjection into raphe magnus modulates cardiorespiratory function in mice and rats
نویسندگان
چکیده
منابع مشابه
Opioid microinjection into raphe magnus modulates cardiorespiratory function in mice and rats.
The raphe magnus (RM) participates in opioid analgesia and contains pain-modulatory neurons with respiration-related discharge. Here, we asked whether RM contributes to respiratory depression, the most prevalent lethal effect of opioids. To investigate whether opioidergic transmission in RM produces respiratory depression, we microinjected a mu-opioid receptor agonist, DAMGO, or morphine into t...
متن کاملNitric oxide in the nucleus raphe magnus modulates cutaneous blood flow in rats during hypothermia
Objective(s): Nucleus Raphe Magnus (NRM) that is involved in the regulation of body temperature contains nitric oxide (NO) synthase. Considering the effect of NO on skin blood flow control, in this study, we assessed its thermoregulatory role within the raphe magnus. Materials and Methods: To this end, tail blood flow of male Wistar rats was measured by laser doppler following the induction of ...
متن کاملnitric oxide in the nucleus raphe magnus modulates cutaneous blood flow in rats during hypothermia
objective(s): nucleus raphe magnus (nrm) that is involved in the regulation of body temperature contains nitric oxide (no) synthase. considering the effect of no on skin blood flow control, in this study, we assessed its thermoregulatory role within the raphe magnus. materials and methods: to this end, tail blood flow of male wistar rats was measured by laser doppler following the induction of ...
متن کاملNitric oxide in the nucleus raphe magnus modulates cutaneous blood flow in rats during hypothermia
OBJECTIVES Nucleus Raphe Magnus (NRM) that is involved in the regulation of body temperature contains nitric oxide (NO) synthase. Considering the effect of NO on skin blood flow control, in this study, we assessed its thermoregulatory role within the raphe magnus. MATERIALS AND METHODS To this end, tail blood flow of male Wistar rats was measured by laser doppler following the induction of hy...
متن کاملTolerance to Non-Opioid Analgesics is Opioid Sensitive in the Nucleus Raphe Magnus
Repeated injection of opioid analgesics can lead to a progressive loss of effect. This phenomenon is known as tolerance. Several lines of investigations have shown that systemic, intraperitoneal administration or the microinjection of non-opioid analgesics, non-steroidal anti-inflammatory drugs (NSAIDs) into the midbrain periaqueductal gray matter induces antinociception with some effects of to...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
سال: 2009
ISSN: 0363-6119,1522-1490
DOI: 10.1152/ajpregu.00140.2009